We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of chitosan-gluconic acid conjugate/poly(vinyl alcohol) cryogels as wound dressing on partial-thickness wounds in diabetic rats.
- Authors
Takei, Takayuki; Nakahara, Hideki; Tanaka, Sadao; Nishimata, Hiroto; Yoshida, Masahiro; Kawakami, Koei
- Abstract
We previously developed chitosan cryogels from chitosan-gluconic acid conjugate without using toxic additives for wound care. In this study, we improved physiological characteristics of the previous cryogels by incorporating poly(vinyl alcohol) that also form cryogels. Mechanical strength of the cryogels was more than two times higher than that of the previous cryogels. Furthermore, the incorporation of poly(vinyl alcohol) enhanced water retention and resistance to degradation of the gels by lysozyme. The cryogels retained the favorable biological properties of the previous cryogels that they accelerate infiltration of inflammatory cells into wound sites. Time period for repairing 50 % of initial area of partial-thickness skin wound treated with the cryogels (4.0 ± 1.1 days) was shorter than those with gauze (6.5 ± 0.3 days) or a commercial hydrogel dressing (5.7 ± 0.3 days). Finally, we confirmed that incorporation of basic fibroblast growth factor into the cryogels was effective to further accelerate wound healing (2.7 ± 1.0 days). These results demonstrate that the cryogels in this study are promising for wound care.
- Subjects
SURGICAL dressings; CHITOSAN; GLUCONIC acid; BIOCONJUGATES; POLYVINYL alcohol; LABORATORY rats; THICKNESS measurement; FIBROBLAST growth factors
- Publication
Journal of Materials Science: Materials in Medicine, 2013, Vol 24, Issue 10, p2479
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-013-4991-5