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- Title
In vitro studies of calcium phosphate silicate bone cements.
- Authors
Zhou, Shuxin; Ma, Jingzhi; Shen, Ya; Haapasalo, Markus; Ruse, N.; Yang, Quanzu; Troczynski, Tom
- Abstract
A novel calcium phosphate silicate bone cement (CPSC) was synthesized in a process, in which nanocomposite forms in situ between calcium silicate hydrate (C-S-H) gel and hydroxyapatite (HAP). The cement powder consists of tricalcium silicate (CS) and calcium phosphate monobasic (CPM). During cement setting, CS hydrates to produce C-S-H and calcium hydroxide (CH); CPM reacts with the CH to precipitate HAP in situ within C-S-H. This process, largely removing CH from the set cement, enhances its biocompatibility and bioactivity. The testing results of cell culture confirmed that the biocompatibility of CPSC was improved as compared to pure CS. The results of XRD and SEM characterizations showed that CPSC paste induced formation of HAP layer after immersion in simulated body fluid for 7 days, suggesting that CPSC was bioactive in vitro. CPSC cement, which has good biocompatibility and low/no cytotoxicity, could be a promising candidate as biomedical cement.
- Subjects
BONE cements; CALCIUM phosphate; HYDROXYAPATITE; BIOCOMPATIBILITY; CALCIUM hydroxide
- Publication
Journal of Materials Science: Materials in Medicine, 2013, Vol 24, Issue 2, p355
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-012-4794-0