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- Title
Redox Properties of the Iron Complexes of Orally Active Iron Chelators CP20, CP502, CP509, and ICL670.
- Authors
Martin Merkofer; Reinhard Kissner; Robert 4;C. Hider; Willem 4;H. Koppenol
- Abstract
Redox cycling of iron is a critical aspect of iron toxicity. Reduction of a low-molecular-weight iron(III)-complex followed by oxidation of the iron(II)-complex by hydrogen peroxide may yield the reactive hydroxyl radical (OH.) or an oxoiron(IV) species (the Fenton reaction). Complexation of iron by a ligand that shifts the electrode potential of the complex to either to far below -350 4;mV (dioxygen/superoxide, pH=7) or to far above +320 4;mV (H2O2/HO., H2O pH=7) is essential for limitting Fenton reactivity. The oral chelating agents CP20, CP502, CP509, and ICL670 effectively remove iron from patients suffering from iron overload. We measured the electrode potentials of the iron(III) complexes of these drugs by cyclic voltammetry with a mercury electrode and determined the dependence on concentration, pH, and stoichiometry. The standard electrode potentials measured are -620 4;mV, -600 4;mV, -535 4;mV, and -535 4;mV with iron bound to CP20, ICL670, CP502, and CP509, respectively, but, at lower chelator concentrations, electrode potentials are significantly higher.
- Subjects
OXIDATION-reduction reaction; HYDROGEN-ion concentration; CHEMICAL reactions; CHEMICAL processes
- Publication
Helvetica Chimica Acta, 2004, Vol 87, Issue 12, p3021
- ISSN
0018-019X
- Publication type
Article