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- Title
A case of an inflammatory myofibroblastic tumor in the lung which expressed TPM3-ALK gene fusion.
- Authors
Kinoshita, Y.; Tajiri, T.; Ieiri, S.; Nagata, K.; Taguchi, T.; Suita, S.; Yamazaki, K.; Yoshino, I.; Maehara, Y.; Kohashi, K.; Yamamoto, H.; Oda, Y.; Tsuneyoshi, M.
- Abstract
We herein describe a 4-year-old boy who after being treated for pneumonia showed an abnormal shadow at the hilus of the right lung on chest X-rays with continued inflammatory findings in his laboratory data. CT and MR investigations suggested the existence of a neoplasm at that site. An open biopsy was thus performed for a definite diagnosis. The histological findings and the expression of TPM3-ALK fusion gene confirmed a diagnosis of an inflammatory myofibroblastic tumor. A right upper and middle lobectomy including the tumor was thus performed for a complete resection. In addition to the histological diagnosis, the detection of the tumor specific fusion gene provided objective evidence in making a diagnosis.
- Subjects
LUNG diseases; CLINICAL pathology; PNEUMONIA in children; MYOFIBROBLASTS; TUMORS; BIOPSY; X-rays; THERAPEUTICS; LUNG tumors; MUSCLE proteins; PROTEIN-tyrosine kinases; PROTEINS; RNA; TRANSFERASES; MUSCLE cells
- Publication
Pediatric Surgery International, 2007, Vol 23, Issue 6, p595
- ISSN
0179-0358
- Publication type
journal article
- DOI
10.1007/s00383-006-1821-6