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- Title
Facile synthesis of a novel polymer/covalent organic framework@silica composite material in deep eutectic solvent for mixed-mode liquid chromatographic separation.
- Authors
Wei, Wanjiao; Zhao, Lulu; Liu, Yanjuan; Zhang, Yuefei; Chen, Wei; Tang, Sheng
- Abstract
The solvothermal synthesis of covalent organic framework (COF) modified silica gel usually requires the use of harmful organic solvents, tedious steps, and harsh reaction conditions. In pursuit of green chemistry, a new strategy for the facile preparation of COF@SiO2 composite material was realized in this work by using a low-toxicity and low-cost deep eutectic solvent as the reaction medium. Additionally, a flexible polyacrylic acid (PAA) was introduced for the purpose of improving the hydrophilic selectivity and separation efficiency of COF@SiO2. Based on the above ideas, a novel PAA/COF@SiO2 composite was successfully developed as a liquid chromatographic packing material. Performance evaluation of the slurry-packed PAA/COF@SiO2 column showed that diverse types of analytes were effectively separated, and the retention behavior of polar nucleosides showed a U-shaped trend, indicating mixed-mode of hydrophobic/hydrophilic retention mechanisms. Thermodynamic studies revealed that the separation mechanism was largely independent of temperature. This work verifies the feasibility of synthesizing polymer/COF@SiO2 composite material in the deep eutectic solvent. This strategy provides a theoretical reference for the green and facile preparation of COF@SiO2 as an efficient liquid chromatographic stationary phase.
- Subjects
COMPOSITE materials; EUTECTICS; POLYMERIZATION; PACKINGS (Chromatography); SILICA gel; SOLVENTS; EUTECTIC reactions; POLYACRYLIC acid
- Publication
Microchimica Acta, 2024, Vol 191, Issue 1, p1
- ISSN
0026-3672
- Publication type
Article
- DOI
10.1007/s00604-023-06116-z