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- Title
Lipophilic Imidazolylpyridines with Antimicrobial Activity.
- Authors
Vedekhina, T. S.; Dogonadze, M. Z.; Vinogradova, T. I.; Chudinov, M. V.; Lukin, A. Yu.
- Abstract
The reaction of nicotinic and isonicotinic propargylamides with lipophilic aliphatic amines yielded a series of 3- or 4-(5-methyl-1H-imidazol-2-yl)pyridines containing a lipophilic substituent in the imidazole ring 1-position. The new compounds were characterized by physicochemical methods. The antituberculosis and antimicrobial activities against ESKAPE pathogens were studied. 3-[1-(1-n-Octadecyl)-5-methyl-1Himidazol-2-yl]pyridine (IIId) had antituberculosis activity (MIC 6.2 μg/mL) while 3-[1-(1-adamantylmethyl)-5-methyl-1H-imidazol-2-yl]pyridine (IIIa) exhibited activity against S. aureus (MIC 16 μg/mL).
- Subjects
ANTI-infective agents; ALIPHATIC amines; PYRIDINE
- Publication
Pharmaceutical Chemistry Journal, 2023, Vol 57, Issue 6, p816
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-023-02954-6