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- Title
Uracil Hydroxybenzamides as Potential Antidiabetic Prodrugs.
- Authors
Brel', A. K.; Spasov, A. A.; Lisina, S. V.; Popov, S. S.; Kucheryavenko, A. F.; Litvinov, R. A.; Salaznikova, O. A.; Rashchenko, A. I.
- Abstract
A series of N1, N3-bis-hydroxybenzoyl, -acetoxybenzoyl, and -methoxybenzoyl uracil derivatives were synthesized. All compounds were screened for the ability to rupture protein cross links and antiglycating, chelating, and antiaggregant properties, which are most significant for pharmacological treatment of thrombosis and angio-, nephro-, encephalo-, and cardiopathies. 1,3-bis-(4-Methoxybenzoyl)pyrimidine-2,4(1H,3H)-dione was a promising antidiabetic agent with all studied activities.
- Subjects
URACIL derivatives; URACIL; PRODRUGS; THROMBOSIS
- Publication
Pharmaceutical Chemistry Journal, 2019, Vol 53, Issue 6, p511
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-019-02029-5