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- Title
Gas-chromatographic determination of methylmethanesulfonate in anti-arthrosis tablets.
- Authors
Kompantsev, D. V.; Ushakova, L. S.; Grigoryan, I. V.; Shcherbakova, L. I.; Kompantseva, E. V.
- Abstract
New tablets possessing anti-arthrosis properties have been created. The basic active agents in this preparation are glucosamine sulfate and methylmethanesulfonate (mesylmethane, MM). It is established that glucosamine in combination with willow-bark extract exhibits more pronounced specific activity. It is suggested to determine the quantitative content of MM by a gas chromatographic (GC) method with the use of a working reference sample. The validation has been carried out. The metrological performance of the proposed method is characterized. The calculated validation parameters confirmed the applicability of GC to the quantification of MM in the anti-arthrosis tablets.
- Subjects
RHEUMATOID arthritis; METHANESULFONATES; GLUCOSAMINE; CHROMATOGRAPHIC analysis; HEXOSAMINES
- Publication
Pharmaceutical Chemistry Journal, 2008, Vol 42, Issue 8, p479
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-008-0154-2