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- Title
Structural genomics of histone tail recognition.
- Authors
Wang, Minghua; Mok, Man Wai; Harper, Hong; Lee, Wen Hwa; Min, Jinrong; Knapp, Stefan; Oppermann, Udo; Marsden, Brian; Schapira, Matthieu
- Abstract
Summary: The structural genomics of histone tail recognition web server is an open access resource that presents within mini articles all publicly available experimental structures of histone tails in complex with human proteins. Each article is composed of interactive 3D slides that dissect the structural mechanism underlying the recognition of specific sequences and histone marks. A concise text html-linked to interactive graphics guides the reader through the main features of the interaction. This resource can be used to analyze and compare binding modes across multiple histone recognition modules, to evaluate the chemical tractability of binding sites involved in epigenetic signaling and design small molecule inhibitors.Availability: http://www.thesgc.org/resources/histone_tails/Contact: matthieu.schapira@utoronto.caSupplementary information: Supplementary data are available at Bioinformatics online.
- Subjects
GENOMICS; HISTONES; INTERNET servers; PROTEINS; BINDING sites; MOLECULES
- Publication
Bioinformatics, 2010, Vol 26, Issue 20, p2629
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btq491