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- Title
Synchronous versus asynchronous modeling of gene regulatory networks.
- Authors
Garg, Abhishek; Cara, Alessandro Di; Xenarios, Ioannis; Mendoza, Luis; De Micheli, Giovanni
- Abstract
Motivation: In silico modeling of gene regulatory networks has gained some momentum recently due to increased interest in analyzing the dynamics of biological systems. This has been further facilitated by the increasing availability of experimental data on gene–gene, protein–protein and gene–protein interactions. The two dynamical properties that are often experimentally testable are perturbations and stable steady states. Although a lot of work has been done on the identification of steady states, not much work has been reported on in silico modeling of cellular differentiation processes.
- Subjects
GENETIC regulation; BIOLOGICAL systems; PROTEIN-protein interactions; CELL differentiation; GENES
- Publication
Bioinformatics, 2008, Vol 24, Issue 17, p1917
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btn336