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- Title
Sensitivity, Specificity, PPV, and NPV for Predictive Biomarkers.
- Authors
Simon, Richard
- Abstract
Molecularly targeted cancer drugs are often developed with companion diagnostics that attempt to identify which patients will have better outcome on the new drug than the control regimen. Such predictive biomarkers are playing an increasingly important role in precision oncology. For diagnostic tests, sensitivity, specificity, positive predictive value, and negative predictive are usually used as performance measures. This paper discusses these indices for predictive biomarkers, provides methods for their calculation with survival or response endpoints, and describes assumptions involved in their use.
- Subjects
ANTINEOPLASTIC agents; BIOMARKERS; ONCOLOGY; CANCER diagnosis; CLINICAL pathology
- Publication
JNCI: Journal of the National Cancer Institute, 2015, Vol 107, Issue 8, p1
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djv153