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- Title
MCF-7 Cells--Changing the Course of Breast Cancer Research and Care for 45 Years.
- Authors
Lee, Adrian V.; Oesterreich, Stefi; Davidson, Nancy E.
- Abstract
It is 45 years since a pleural effusion from a patient with metastatic breast cancer led to the generation of the MCF-7 breast cancer cell line. MCF-7 is the most studied human breast cancer cell line in the world, and results from this cell line have had a fundamental impact upon breast cancer research and patient outcomes. But of the authors for the nearly 25 000 scientific publications that used this cell line, how many know the unique story of its isolation and development? In this commentary we will review the past, present, and future of research using MCF-7 breast cancer cells.
- Subjects
CANCER cells; BREAST cancer research; BREAST cancer treatment; BREAST cancer patients; CELL lines
- Publication
JNCI: Journal of the National Cancer Institute, 2015, Vol 107, Issue 7, p1
- ISSN
0027-8874
- Publication type
Opinion
- DOI
10.1093/jnci/djv073