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- Title
The Correlation of Serum Calpain 1 Activity and Concentrations of Interleukin 33 in COVID-19 Acute Respiratory Distress Syndrome.
- Authors
Loinjak, Domagoj; Mihić, Damir; Smolić, Robert; Maričić, Lana; Šahinović, Ines; Smolić, Martina; Sikora, Renata; Loinjak, Sanja; Dinjar, Kristijan; Včev, Aleksandar
- Abstract
Acute respiratory distress syndrome (ARDS) is one of the most severe complications of the COVID-19 disease. The role of IL-33 and calpain 1 was previously described in lung infections and lung tissue damage. Our study examined the association between serum calpain 1 activity and IL-33 concentration in patients with COVID-19 ARDS. In the research, we included 80 subjects who had COVID-19 pneumonia and divided them into 2 groups: 40 subjects with ARDS and 40 subjects without ARDS. The basis of the research was the collection of subjects' data and the sampling of peripheral venous blood. The concentration of IL-33 was determined by the ELISA method and the activity of calpain 1 by the fluorometry method. Our research showed elevated calpain 1 activity and IL-33 concentration in the serum of COVID-19 patients who developed ARDS compared to those who did not develop ARDS and a positive correlation between them was established. Further, a positive correlation was established between the examined parameters and the severity of the disease, proinflammatory markers, and the use of mechanical ventilation. These results indicate a possible association and role of calpain 1 and IL-33 with the development of ARDS in COVID-19 patients.
- Subjects
ADULT respiratory distress syndrome; CALPAIN; COVID-19
- Publication
Biomedicines, 2023, Vol 11, Issue 7, p1847
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines11071847