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- Title
Expedient Synthesis of Coumarin–1,2,3-Triazole Hybrids via Click Chemistry and Their Antimicrobial Evaluation.
- Authors
Kangad, S. K.; Patolia, V. N.; Sitapara, S. M.; Maliwal, D.; Pashavan, C.; Pissurlenkar, R. R. S.
- Abstract
This study focuses on the synthesis of aromatic and heteroaromatic triazole derivatives known for their versatile therapeutic potential in the treatment of cancer, bacterial infections, fungal infections, and malaria. To achieve this, we have developed an efficient synthetic pathway for a wide range of derivatives with a structural motif represented as 2-(4-{[(2-oxo-2H-chromen-4-yl)oxy]methyl}-1H-1,2,3-triazol-1-yl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide. The structure of the synthesized compounds was determined using 1H and 13C NMR spectroscopy, FT-IR spectroscopy, mass spectrometry, and elemental analysis. Furthermore, this study delves into the antimicrobial and antifungal properties of the coumarin-linked triazole derivatives, highlighting their potential as diverse chemotherapeutic agents with promising clinical applications. Also, the in silico study was performed to assess pharmacokinetics and toxicity profiles.
- Subjects
CLICK chemistry; CHEMICAL synthesis; TRIAZOLE derivatives; NUCLEAR magnetic resonance spectroscopy; MYCOSES; COUMARINS; QUINAZOLINONES; ACETAMIDE derivatives
- Publication
Russian Journal of Organic Chemistry, 2024, Vol 60, Issue 4, p734
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428024040249