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- Title
Alkylation of Ethyl 2-Aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylates with Benzyl Halides.
- Authors
Nikitina, P. A.; Os'kina, I. A.; Nikolaenkova, E. B.; Kulikova, E. A.; Miroshnikov, V. S.; Perevalov, V. P.; Tikhonov, A. Ya.
- Abstract
The alkylation of ethyl 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylates with substituted benzyl halides resulted in the selective formation of O-alkoxy derivatives. N-Alkylation products (1-alkylimidazole 3-oxides) were obtained by the condensation reaction from acyclic starting compounds. In the presence of the 2-hydroxyphenyl substituent in the 2-position of the imidazole ring, selective monoalkylation involving the hydroxyl substituent on the imidazole nitrogen takes place.
- Subjects
BENZYL halides; CONDENSATION reactions; ALKYLATION; IMIDAZOLES; ALKOXY compounds
- Publication
Russian Journal of Organic Chemistry, 2024, Vol 60, Issue 2, p243
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S107042802402009X