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- Title
Reaction of 6-Oxocyclohexane-1,3-dicarboxamides with Binucleophilic Reagents. Antinociceptive Activity of the Synthesized Hydrazones and 2,3,4,5,6,7-Hexahydro-1H-indazoles.
- Authors
Gein, V. L.; Lezhnina, D. D.; Nosova, N. V.; Makhmudov, R.R.; Dmitriev, M. V.
- Abstract
Novel hydrazones and hexahydro-1H-indazole-5-carboxamides were obtained via the reaction of 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides with tosylhydrazide, 2,4-dinitrophenylhydrazine, and phenylhydrazine, respectively. The structures of the products were proved by IR and 1H and 13C NMR spectroscopy, as well as X-ray diffraction analysis. The synthesized compounds were tested for antinociceptive activity.
- Subjects
HYDRAZONES; NUCLEAR magnetic resonance spectroscopy; CHEMICAL synthesis; X-ray diffraction; PHENYLHYDRAZINE
- Publication
Russian Journal of Organic Chemistry, 2022, Vol 58, Issue 11, p1610
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428022110070