We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Managing Severe Adverse Reactions to Biologicals in Severe Asthma.
- Authors
Balan, Radu-Gheorghe; Deleanu, Diana Mihaela; Pintea, Irena; Dobrican Baruta, Carmen Teodora; Man, Milena Adina; Bocsan, Ioana Corina; Muntean, Ioana Adriana
- Abstract
Background: The use of biological agents in the treatment of various inflammatory and malignancy conditions has expanded rapidly. However, these agents can induce hypersensitivity reactions, posing significant clinical challenges. Methods: We conducted a retrospective study that included nine patients with severe asthma who experienced hypersensitivity reactions to biological agents (omalizumab, benralizumab and dupilumab). Results: Hypersensitivity reactions to biologicals in severe asthma were observed in 9 of 68 patients treated. In five cases, treatment was stopped or changed to another available biological, and for four patients administered under close surveillance, titrated provocation or desensitization was applied. Successful desensitization was achieved in three of the patients, allowing them to continue therapy without adverse reactions. Improvements in asthma control were observed post-desensitization, leading to the reduced need for systemic steroid treatments and an increase in quality of life. Conclusions: This study highlights the importance of recognizing hypersensitivity reactions to biologicals to have an appropriate approach for patients with severe asthma. As an effective approach for patients experiencing hypersensitivity reactions to biological agents, desensitization allows treatment continuation.
- Subjects
PATIENT experience; BIOLOGICALS; ASTHMATICS; ASTHMA; DUPILUMAB; VOCAL cord dysfunction
- Publication
Biomedicines, 2023, Vol 11, Issue 12, p3108
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines11123108