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- Title
Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer's Disease.
- Authors
López-Cuenca, Inés; de Hoz, Rosa; Alcántara-Rey, Celia; Salobrar-García, Elena; Elvira-Hurtado, Lorena; Fernández-Albarral, José A.; Barabash, Ana; Ramírez-Toraño, Federico; de Frutos-Lucas, Jaisalmer; Salazar, Juan J.; Ramírez, Ana I.; Ramírez, José M.
- Abstract
A family history (FH+) of Alzheimer's disease (AD) and ɛ4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ɛ4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported in both pathologies. We analyzed the choroidal thickness using optical coherence tomography (OCT) and the foveal avascular zone (FAZ) using OCT-angiography and compared the results with ApoE gene expression, AD FH+, and the presence or absence of hard drusen (HD) in 184 cognitively healthy subjects. Choroidal thickness was statistically significantly different in the (FH−, ɛ4−, HD+) group compared with (i) both the (FH−, ɛ4−, HD−) and the (FH+, ɛ4+, HD+) groups in the superior and inferior points at 1500 μm, and (ii) the (FH+, ɛ4−, HD+) group in the superior point at 1500 μm. There were statistically significant differences in the superficial FAZ between the (FH+, ɛ4−, HD+) group and (i) the (FH+, ɛ4−, HD−) group and (ii) the (FH+, ɛ4+, HD−) group. In conclusion, ocular vascular changes are not yet evident in participants with a genetic risk of developing AD.
- Subjects
CHOROID; ALZHEIMER'S disease; OPTICAL coherence tomography; RETINAL degeneration; GENE expression
- Publication
Biomedicines, 2021, Vol 9, Issue 6, p638
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines9060638