We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacological Treatment of Dementia: A Scoping Review of Systematic Reviews.
- Authors
van de Glind, Esther M.M.; van Enst, Wynanda A.; van Munster, Barbara C.; Olde Rikkert, Marcel G.M.; Scheltens, Philip; Scholten, Rob J.P.M.; Hooft, Lotty
- Abstract
Background: Until now, multiple reviews on the pharmacological treatment of dementia have been published. Methods: We performed a scoping review to summarize research findings and to identify gaps in the existing literature. We searched the literature and assessed the risk of bias of the included reviews. A team of clinical experts assessed the fields in which more research is necessary. Fifty-five reviews with a low risk of bias were included, most of them concerning the treatment of cognitive decline (n = 16) and behavioral symptoms (n = 10) in Alzheimer's disease (AD). For cognitive impairment, cholinesterase inhibitors (n = 13) and memantine (n = 7) were described most frequently. Little information was found about the treatment of depression in dementia. Conclusions: For many current treatments, there is sufficient evidence. New research should focus on the symptomatic treatment of the earliest and most salient complaints in AD as well as on disease-modifying interventions acting at the level of the amyloid cascade. © 2013 S. Karger AG, Basel
- Subjects
NETHERLANDS; ALZHEIMER'S disease; CINAHL database; DEMENTIA; MENTAL depression; DRUGS; EXPERTISE; INFORMATION storage &; retrieval systems; MEDICAL databases; MEDICAL information storage &; retrieval systems; PSYCHOLOGY information storage &; retrieval systems; MEDICAL personnel; MEDLINE; SYSTEMATIC reviews; EVIDENCE-based medicine; AGITATION (Psychology); PROFESSIONAL practice; CONCEPT mapping; SYMPTOMS
- Publication
Dementia & Geriatric Cognitive Disorders, 2013, Vol 36, Issue 3/4, p211
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000353892