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- Title
Cancer and pulmonary hypertension: Learning lessons and real-life interplay.
- Authors
Pullamsetti, Soni Savai; Nayakanti, Sreenath; Chelladurai, Prakash; Mamazhakypov, Argen; Mansouri, Siavash; Savai, Rajkumar; Seeger, Werner
- Abstract
This article reviews the scientific reasons that support the intriguing vision of pulmonary hypertension (PH) as a disease with a cancer-like nature and to understand whether this point of view may have fruitful consequences for the overall management of PH. This review compares cancer and PH in view of Hanahan and Weinberg's principles (i.e., hallmarks of cancer) with an emphasis on hyperproliferative, metabolic, and immune/inflammatory aspects of the disease. In addition, this review provides a perspective on the role of transcription factors and chromatin and epigenetic aberrations, besides genetics, as "common driving mechanisms" of PH hallmarks and the foreseeable use of transcription factor/epigenome targeting as multitarget approach against the hallmarks of PH. Thus, recognition of the widespread applicability and analogy of these concepts will increasingly affect the development of new means of PH treatment.
- Subjects
PULMONARY hypertension; TRANSCRIPTION factors; GENETICS
- Publication
Global Cardiology Science & Practice, 2020, Vol 2020, Issue 1, p1
- ISSN
2305-7823
- Publication type
Article
- DOI
10.21542/gcsp.2020.10