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- Title
Effectiveness and safety of major systemic treatments in classic and endemic Kaposi sarcoma: a multicentre retrospective study of 110 patients.
- Authors
Grolleau, Chloé; Walter-Petrich, Anouk; Dupin, Nicolas; Chanal, Johan; Zehou, Ouidad; Montlahuc, Claire; Baroudjian, Barouyr; Meda, Laetitia Da; Resche-Rigon, Matthieu; Cleach, Laurence Le; Lebbé, Céleste
- Abstract
This article presents the findings of a study on the treatment of Kaposi sarcoma (KS), a type of cancer that primarily affects the skin and mucous membranes. The study analyzed the effectiveness and safety of different treatment regimens for KS. The results showed that liposomal doxorubicin (LD), paclitaxel, and low-dose interferon (LDI) were all effective treatments for KS. However, LDI had a lower response rate compared to paclitaxel, and a similar trend was observed when comparing LDI to LD. The study also found that the subtype of KS, age at treatment initiation, and systemic involvement did not significantly affect treatment response. The study highlighted the importance of head-to-head trials to further evaluate these treatments and emphasized the poor prognosis associated with ulcerated lesions and systemic localization at diagnosis. Additionally, the study found that response rates to treatment decreased with successive lines of treatment in endemic KS (EKS) compared to classic KS (CKS), indicating the more aggressive nature of EKS. The study was limited by its retrospective design.
- Subjects
KAPOSI'S sarcoma; PARACOCCIDIOIDOMYCOSIS
- Publication
British Journal of Dermatology, 2024, Vol 190, Issue 5, p771
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1093/bjd/ljae032