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- Title
Pure red cell aplasia induced by epoetin zeta.
- Authors
Panichi, Vincenzo; Ricchiuti, Guido; Scatena, Alessia; Del Vecchio, Lucia; Locatelli, Francesco
- Abstract
Pure red cell aplasia (PRCA) may develop in patients with chronic kidney disease receiving erythropoiesis-stimulating agents (ESA). We report on a 72-year-old patient who developed hypo-proliferative anaemia unresponsive to ESA following the administration of epoetin zeta subcutaneously for 7 months. On the basis of severe isolated hypoplasia of the erythroid line in the bone marrow and high-titre neutralizing anti-erythropoietin antibodies (Ab), a diagnosis of Ab-mediated PRCA was made. Epoetin zeta was discontinued and the patient was given steroids. This was associated with anaemia recovery. To our knowledge this is the first PRCA case related to epoetin zeta.
- Subjects
EPOETIN alfa (Drug)
- Publication
Clinical Kidney Journal, 2016, Vol 9, Issue 4, p599
- ISSN
2048-8505
- Publication type
Case Study
- DOI
10.1093/ckj/sfw030