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- Title
Allogeneic bone marrow transplantation for juvenile myelomonocytic leukemia: a single center experience of 23 patients.
- Authors
Korthof, E. T.; Snijder, P. P.; de Graaff, A. A.; Lankester, A. C.; Bredius, R. G. M.; Ball, L. M.; Lie, J. L. W. T.; Vossen, J. M.; Egeler, R. M.
- Abstract
Summary:Juvenile myelomonocytic leukemia (JMML) is a childhood leukemia for which allogeneic BMT is the only curative therapy. At our pediatric stem cell transplantation unit, we performed 26 BMTs in 23 children (age 0.5-12.7 years). Conditioning was CY/TBI based (1980-1996, n=14) or BU/CY/melphalan based (1996-2001, n=9). Donors were HLA-identical siblings (n=11), unrelated volunteers (n=9) or mismatched family members (n=3). A total of 10 patients survive in CR (median follow-up 6.8 years, range 3.1-22.2 years). Relapse or persistent disease was observed in eight and two patients, respectively. Nine of these patients died, one achieved a second remission following acute nonlymphatic leukemia chemotherapy (duration to date 5.3 years). Transplant-related mortality occurred in four patients. Overall survival at 5 and 10 years was 43.5%. Using T-cell-depleted, one-antigen mismatched unrelated donors was the only significant adverse factor associated with relapse in multivariate analysis (P=0.039, hazard ratio 4.9). Together with a trend towards less relapse in patients with graft-versus-host-disease and in patients transplanted with matched unrelated donors, this suggests a graft-versus-leukemia effect of allogeneic BMT in JMML.Bone Marrow Transplantation (2005) 35, 455-461. doi:10.1038/sj.bmt.1704778 Published online 17 January 2005
- Subjects
LEUKEMIA in children; BONE marrow transplantation; CANCER chemotherapy; LEUKEMIA; STEM cell transplantation; T cells; CLINICAL trials
- Publication
Bone Marrow Transplantation, 2005, Vol 35, Issue 5, p455
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1704778