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- Title
Mesial temporal sclerosis - a late complication in four allogeneic pediatric recipients with persistent seizures after an acute episode of cyclosporine-A neurotoxicity.
- Authors
Faraci, M; Lanino, E; Dallorso, S; Morreale, G; Cappelli, B; Gaggero, R; Dini, G; Haupt, R; Fondelli, M P
- Abstract
Summary:Mesial temporal sclerosis (MTS) is a common finding in patients with intractable temporal lobe epilepsy (TLE). In this report, we retrospectively reviewed the neuroimaging results of four children who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), and who developed recurrent, partial, intractable seizures following a first event caused by cyclosporine-A (CSA) neurotoxicity. Neuroradiologic findings of MTS were demonstrated in all these patients. We suggest that MTS may be a consequence of CSA neurotoxicity, which induces repeated seizures, associated with other predisposing conditions, as well as being a consequence of the underlying disease and its treatment, and of severe graft-versus-host disease (GvHD).Bone Marrow Transplantation (2003) 31, 919-922. doi:10.1038/sj.bmt.1704023
- Subjects
PEDIATRIC neurology; HEMATOPOIETIC stem cell transplantation; CYCLOSPORINE; NEUROTOXICOLOGY
- Publication
Bone Marrow Transplantation, 2003, Vol 31, Issue 10, p919
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1704023