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Towards the Development of a Minigenome Assay for Species A Rotaviruses.
Published in:
Viruses (1999-4915), 2024, v. 16, n. 9, p. 1396, doi. 10.3390/v16091396
By:
- Diebold, Ola;
- Zhou, Shu;
- Sharp, Colin Peter;
- Tesla, Blanka;
- Chook, Hou Wei;
- Digard, Paul;
- Gaunt, Eleanor R.
Publication type:
Article
A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance.
Published in:
BMC Genomics, 2015, v. 16, n. 1, p. 1, doi. 10.1186/s12864-015-1778-8
By:
- Smith, Jacqueline;
- Smith, Nikki;
- Le Yu;
- Paton, Ian R.;
- Gutowska, Maria Weronika;
- Forrest, Heather L.;
- Danner, Angela F.;
- Seiler, J. Patrick;
- Digard, Paul;
- Webster, Robert G.;
- Burt, David W.
Publication type:
Article
A quantitative proteomic analysis of lung epithelial (A549) cells infected with 2009 pandemic influenza A virus using stable isotope labelling with amino acids in cell culture.
Published in:
Proteomics, 2012, v. 12, n. 9, p. 1431, doi. 10.1002/pmic.201100470
By:
- Dove, Brian K.;
- Surtees, Rebecca;
- Bean, Thomas J.H.;
- Munday, Diane;
- Wise, Helen M.;
- Digard, Paul;
- Carroll, Miles W.;
- Ajuh, Paul;
- Barr, John N.;
- Hiscox, Julian A.
Publication type:
Article
Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes.
Published in:
Proteomics, 2012, v. 12, n. 4/5, p. 666, doi. 10.1002/pmic.201100488
By:
- Munday, Diane C.;
- Surtees, Rebecca;
- Emmott, Edward;
- Dove, Brian K.;
- Digard, Paul;
- Barr, John N.;
- Whitehouse, Adrian;
- Matthews, David;
- Hiscox, Julian A.
Publication type:
Article
Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection.
Published in:
eLife, 2016, p. 1, doi. 10.7554/eLife.12735
By:
- Gaunt, Eleanor;
- Wise, Helen M.;
- Huayu Zhang;
- Lee, Lian N.;
- Atkinson, Nicky J.;
- Nicol, Marlynne Quigg;
- Highton, Andrew J.;
- Klenerman, Paul;
- Beard, Philippa M.;
- Dutia, Bernadette M.;
- Digard, Paul;
- Simmonds, Peter
Publication type:
Article
TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway.
Published in:
Nucleic Acids Research, 2022, v. 50, n. 12, p. 7097, doi. 10.1093/nar/gkac512
By:
- Choudhury, Nila Roy;
- Trus, Ivan;
- Heikel, Gregory;
- Wolczyk, Magdalena;
- Szymanski, Jacek;
- Bolembach, Agnieszka;
- Dos Santos Pinto, Rute Maria;
- Smith, Nikki;
- Trubitsyna, Maryia;
- Gaunt, Eleanor;
- Digard, Paul;
- Michlewski, Gracjan
Publication type:
Article
Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-019-13965-x
By:
- Li, Bo;
- Clohisey, Sara M.;
- Chia, Bing Shao;
- Wang, Bo;
- Cui, Ang;
- Eisenhaure, Thomas;
- Schweitzer, Lawrence D.;
- Hoover, Paul;
- Parkinson, Nicholas J.;
- Nachshon, Aharon;
- Smith, Nikki;
- Regan, Tim;
- Farr, David;
- Gutmann, Michael U.;
- Bukhari, Syed Irfan;
- Law, Andrew;
- Sangesland, Maya;
- Gat-Viks, Irit;
- Digard, Paul;
- Vasudevan, Shobha
Publication type:
Article
Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes.
Published in:
Virology Journal, 2006, v. 3, p. 58, doi. 10.1186/1743-422X-3-58
By:
- Dalton, Rosa M.;
- Mullin, Anne E.;
- Amorim, Maria Joao;
- Medcalf, Elizabeth;
- Tiley, Laurence S.;
- Digard, Paul
Publication type:
Article
Validation of Candidate Host Cell Entry Factors for Bovine Herpes Virus Type-1 Based on a Genome-Wide CRISPR Knockout Screen.
Published in:
Viruses (1999-4915), 2024, v. 16, n. 2, p. 297, doi. 10.3390/v16020297
By:
- Tan, Wenfang Spring;
- Rong, Enguang;
- Dry, Inga;
- Lillico, Simon;
- Law, Andy;
- Digard, Paul;
- Whitelaw, Bruce;
- Dalziel, Robert G.
Publication type:
Article
Comparative Analysis of Different Inbred Chicken Lines Highlights How a Hereditary Inflammatory State Affects Susceptibility to Avian Influenza Virus.
Published in:
Viruses (1999-4915), 2023, v. 15, n. 3, p. 591, doi. 10.3390/v15030591
By:
- Bryson, Karen J.;
- Sives, Samantha;
- Lee, Hui-Min;
- Borowska, Dominika;
- Smith, Jacqueline;
- Digard, Paul;
- Vervelde, Lonneke
Publication type:
Article
Identification of a Novel Splice Variant Form of the Influenza A Virus M2 Ion Channel with an Antigenically Distinct Ectodomain.
Published in:
PLoS Pathogens, 2012, v. 8, n. 11, p. 1, doi. 10.1371/journal.ppat.1002998
By:
- Wise, Helen M.;
- Hutchinson, Edward C.;
- Jagger, Brett W.;
- Stuart, Amanda D.;
- Kang, Zi H.;
- Robb, Nicole;
- Schwartzman, Louis M.;
- Kash, John C.;
- Fodor, Ervin;
- Firth, Andrew E.;
- Gog, Julia R.;
- Taubenberger, Jeffery K.;
- Digard, Paul
Publication type:
Article
A chicken bioreactor for efficient production of functional cytokines.
Published in:
BMC Biotechnology, 2018, v. 18, n. 1, p. N.PAG, doi. 10.1186/s12896-018-0495-1
By:
- Smith, Nikki;
- Lillico, Simon;
- Sherman, Adrian;
- Gilhooley, Hazel J.;
- Kurian, Dominic;
- Digard, Paul;
- Sang, Helen M.;
- Herron, Lissa R.;
- Pridans, Clare;
- Hume, David A.;
- Turnbull, Matthew L.;
- Gill, Andrew C.;
- Papadakos, Grigorios;
- Wear, Martin
Publication type:
Article
Engineered Recombinant Single Chain Variable Fragment of Monoclonal Antibody Provides Protection to Chickens Infected with H9N2 Avian Influenza.
Published in:
Vaccines, 2020, v. 8, n. 1, p. 118, doi. 10.3390/vaccines8010118
By:
- Lukosaityte, Deimante;
- Sadeyen, Jean-Remy;
- Shrestha, Angita;
- Sealy, Joshua E.;
- Bhat, Sushant;
- Chang, Pengxiang;
- Digard, Paul;
- Iqbal, Munir
Publication type:
Article
Effects of mutations in the effector domain of influenza A virus NS1 protein.
Published in:
BMC Research Notes, 2018, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13104-018-3779-6
By:
- Pereira, Carina F.;
- Wise, Helen M.;
- Kurian, Dominic;
- Pinto, Rute M.;
- Amorim, Maria J.;
- Gill, Andrew C.;
- Digard, Paul
Publication type:
Article
GARP and EARP are required for efficient BoHV-1 replication as identified by a genome wide CRISPR knockout screen.
Published in:
PLoS Pathogens, 2023, v. 19, n. 12, p. 1, doi. 10.1371/journal.ppat.1011822
By:
- Tan, Wenfang S.;
- Rong, Enguang;
- Dry, Inga;
- Lillico, Simon G.;
- Law, Andy;
- Digard, Paul;
- Whitelaw, Bruce;
- Dalziel, Robert G.
Publication type:
Article
CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy.
Published in:
PLoS Pathogens, 2023, v. 18, n. 5, p. 1, doi. 10.1371/journal.ppat.1011357
By:
- Sharp, Colin P.;
- Thompson, Beth H.;
- Nash, Tessa J.;
- Diebold, Ola;
- Pinto, Rute M.;
- Thorley, Luke;
- Lin, Yao-Tang;
- Sives, Samantha;
- Wise, Helen;
- Clohisey Hendry, Sara;
- Grey, Finn;
- Vervelde, Lonneke;
- Simmonds, Peter;
- Digard, Paul;
- Gaunt, Eleanor R.
Publication type:
Article
Intra-genome variability in the dinucleotide composition of SARS-CoV-2.
Published in:
Virus Evolution, 2020, v. 6, n. 2, p. 1, doi. 10.1093/ve/veaa057
By:
- Digard, Paul;
- Lee, Hui Min;
- Sharp, Colin;
- Grey, Finn;
- Gaunt, Eleanor
Publication type:
Article
Nuclear Export of Influenza A Virus mRNAs Requires Ongoing RNA Polymerase II Activity.
Published in:
Traffic, 2007, v. 8, n. 1, p. 1, doi. 10.1111/j.1600-0854.2006.00507.x
By:
- Amorim, Maria-Joao;
- Read, Eliot K.;
- Dalton, Rosa M.;
- Medcalf, Liz;
- Digard, Paul
Publication type:
Article
Lipid Raft-Dependent Targeting of the Influenza A Virus Nucleoprotein to the Apical Plasma Membrane.
Published in:
Traffic, 2004, v. 5, n. 12, p. 979, doi. 10.1111/j.1600-0854.2004.00237.x
By:
- Carrasco, Marlene;
- Amorim, Maria Joao;
- Digard, Paul
Publication type:
Article
Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection.
Published in:
Frontiers in Cellular & Infection Microbiology, 2021, v. 11, p. 1, doi. 10.3389/fcimb.2021.689707
By:
- Charman, Matthew;
- McFarlane, Steven;
- Wojtus, Joanna K.;
- Sloan, Elizabeth;
- Dewar, Rebecca;
- Leeming, Gail;
- Al-Saadi, Mohammed;
- Hunter, Laura;
- Carroll, Miles W.;
- Stewart, James P.;
- Digard, Paul;
- Hutchinson, Edward;
- Boutell, Chris
Publication type:
Article
Precision cut lung slices: a novel versatile tool to examine host–pathogen interaction in the chicken lung.
Published in:
Veterinary Research, 2020, v. 51, n. 1, p. 1, doi. 10.1186/s13567-019-0733-0
By:
- Bryson, Karen Jane;
- Garrido, Damien;
- Esposito, Marco;
- McLachlan, Gerry;
- Digard, Paul;
- Schouler, Catherine;
- Guabiraba, Rodrigo;
- Trapp, Sascha;
- Vervelde, Lonneke
Publication type:
Article
Expression of HIV-1 Vpu Leads to Loss of the Viral Restriction Factor CD317/Tetherin from Lipid Rafts and Its Enhanced Lysosomal Degradation.
Published in:
PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0075680
By:
- Rollason, Ruth;
- Dunstan, Katie;
- Billcliff, Peter G.;
- Bishop, Paul;
- Gleeson, Paul;
- Wise, Helen;
- Digard, Paul;
- Banting, George
Publication type:
Article
I223R Mutation in Influenza A(H1N1)pdm09 Neuraminidase Confers Reduced Susceptibility to Oseltamivir and Zanamivir and Enhanced Resistance with H275Y.
Published in:
PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0037095
By:
- Legoff, Jérome;
- Rousset, Dominique;
- Abou-Jaoudé, Georges;
- Scemla, Anne;
- Ribaud, Patricia;
- Mercier-Delarue, Séverine;
- Caro, Valérie;
- Enouf, Vincent;
- Simon, François;
- Molina, Jean-Michel;
- Van Der Werf, Sylvie;
- Digard, Paul
Publication type:
Article
Survival of Influenza A(H1N1) on Materials Found in Households: Implications for Infection Control.
Published in:
PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0027932
By:
- Greatorex, Jane S.;
- Digard, Paul;
- Curran, Martin D.;
- Moynihan, Robert;
- Wensley, Harrison;
- Wreghitt, Tim;
- Varsani, Harsha;
- Garcia, Fayna;
- Enstone, Joanne;
- Nguyen-Van-Tam, Jonathan S.
Publication type:
Article
Effectiveness of Common Household Cleaning Agents in Reducing the Viability of Human Influenza A/H1N1.
Published in:
PLoS ONE, 2010, v. 5, n. 2, p. 1, doi. 10.1371/journal.pone.0008987
By:
- Greatorex, Jane S.;
- Page, Rosanna F.;
- Curran, Martin D.;
- Digard, Paul;
- Enstone, Joanne E.;
- Wreghitt, Tim;
- Powell, Penny P.;
- Sexton, Darren W.;
- Vivancos, Roberto;
- Nguyen-Van-Tam, Jonathan S.
Publication type:
Article
Role of the Rab11 pathway in negative-strand virus assembly.
Published in:
Biochemical Society Transactions, 2012, v. 40, n. 6, p. 1409, doi. 10.1042/BST20120166
By:
- Bruce, Emily A.;
- Stuart, Amanda;
- McCaffrey, Mary W.;
- Digard, Paul
Publication type:
Article
Modelling the Structure and Dynamics of Biological Pathways.
Published in:
PLoS Biology, 2016, v. 14, n. 8, p. 1, doi. 10.1371/journal.pbio.1002530
By:
- O’Hara, Laura;
- Livigni, Alessandra;
- Theo, Thanos;
- Boyer, Benjamin;
- Angus, Tim;
- Wright, Derek;
- Chen, Sz-Hau;
- Raza, Sobia;
- Barnett, Mark W.;
- Digard, Paul;
- Smith, Lee B.;
- Freeman, Tom C.
Publication type:
Article
Novel Avian Influenza Virus (H5N1) Clade 2.3.4.4b Reassortants in Migratory Birds, China.
Published in:
Emerging Infectious Diseases, 2023, v. 29, n. 6, p. 1244, doi. 10.3201/eid2906.221723
By:
- Jing Yang;
- Chunge Zhang;
- Yue Yuan;
- Ju Sun;
- Lu Lu;
- Honglei Sun;
- Heting Sun;
- Dong Chu;
- Siyuan Qin;
- Jianjun Chen;
- Chengbo Zhang;
- Xiyan Hao;
- Weifeng Shi;
- Wenjun Liu;
- Gao, George F.;
- Digard, Paul;
- Lycett, Samantha;
- Yuhai Bi
Publication type:
Article
The genetics of virus particle shape in equine influenza A virus.
Published in:
Influenza & Other Respiratory Viruses, 2013, v. 7, p. 81, doi. 10.1111/irv.12197
By:
- Elton, Debra;
- Bruce, Emily A.;
- Bryant, Neil;
- Wise, Helen M.;
- MacRae, Shona;
- Rash, Adam;
- Smith, Nikki;
- Turnbull, Matthew L.;
- Medcalf, Liz;
- Daly, Janet M.;
- Digard, Paul
Publication type:
Article
Overlapping signals for translational regulation and packaging of influenza A virus segment 2.
Published in:
Nucleic Acids Research, 2011, v. 39, n. 17, p. 7775, doi. 10.1093/nar/gkr487
By:
- Wise, Helen M.;
- Barbezange, Cyril;
- Jagger, Brett W.;
- Dalton, Rosa M.;
- Gog, Julia R.;
- Curran, Martin D.;
- Taubenberger, Jeffery K.;
- Anderson, Emma C.;
- Digard, Paul
Publication type:
Article
Codon conservation in the influenza A virus genome defines RNA packaging signals.
Published in:
Nucleic Acids Research, 2007, v. 35, n. 6, p. 1897, doi. 10.1093/nar/gkm087
By:
- Gog, Julia R.;
- Afonso, Emmanuel Dos Santos;
- Dalton, Rosa M.;
- Leclercq, India;
- Tiley, Laurence;
- Elton, Debra;
- von Kirchbach, Johann C.;
- Naffakh, Nadia;
- Escriou, Nicolas;
- Digard, Paul
Publication type:
Article
Activation of influenza virus RNA polymerase by the 5′ and 3′ terminal duplex of genomic RNA.
Published in:
Nucleic Acids Research, 2003, v. 31, n. 6, p. 1624, doi. 10.1093/nar/gkg253
By:
- Lee, M.‐T. Michael;
- Klumpp, Klaus;
- Digard, Paul;
- Tiley, Laurence
Publication type:
Article
Definition of the minimal viral components required for the initiation of unprimed RNA synthesis by influenza virus RNA polymerase.
Published in:
Nucleic Acids Research, 2002, v. 30, n. 2, p. 429, doi. 10.1093/nar/30.2.429
By:
- Lee, M. T. Michael;
- Bishop, Konrad;
- Medcalf, Liz;
- Elton, Debra;
- Digard, Paul;
- Tiley, Laurence
Publication type:
Article
Comparison of the efficacy of a commercial inactivated influenza A/H1N1/pdm09 virus (pH1N1) vaccine and two experimental M2e-based vaccines against pH1N1 challenge in the growing pig model.
Published in:
PLoS ONE, 2018, v. 13, n. 1, p. 1, doi. 10.1371/journal.pone.0191739
By:
- Opriessnig, Tanja;
- Gauger, Phillip C.;
- Gerber, Priscilla F.;
- Castro, Alessandra M. M. G.;
- Shen, Huigang;
- Murphy, Lita;
- Digard, Paul;
- Halbur, Patrick G.;
- Xia, Ming;
- Jiang, Xi;
- Tan, Ming
Publication type:
Article
Evidence that the C-terminal PB2-binding region of the influenza A virus PB1 protein is a discrete α-helical domain
Published in:
FEBS Letters, 2007, v. 581, n. 27, p. 5300, doi. 10.1016/j.febslet.2007.10.025
By:
- Poole, Emma L.;
- Medcalf, Liz;
- Elton, Debra;
- Digard, Paul
Publication type:
Article
The molecular basis of differential host responses to avian influenza viruses in avian species with differing susceptibility.
Published in:
Frontiers in Cellular & Infection Microbiology, 2023, v. 13, p. 1, doi. 10.3389/fcimb.2023.1067993
By:
- Morris, Katrina M.;
- Mishra, Anamika;
- Raut, Ashwin A.;
- Gaunt, Eleanor R.;
- Borowska, Dominika;
- Kuo, Richard I.;
- Bo Wang;
- Vijayakumar, Periyasamy;
- Chingtham, Santhalembi;
- Dutta, Rupam;
- Baillie, Kenneth;
- Digard, Paul;
- Vervelde, Lonneke;
- Burt, David W.;
- Smith, Jacqueline
Publication type:
Article
Compositional biases in RNA viruses: Causes, consequences and applications.
Published in:
Wiley Interdisciplinary Reviews: RNA, 2022, v. 13, n. 2, p. 1, doi. 10.1002/wrna.1679
By:
- Gaunt, Eleanor R.;
- Digard, Paul
Publication type:
Article

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