We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Peeling the onion: NMDA dysfunction a unifying model in schizophrenia.
- Authors
Javitt, Daniel C.
- Abstract
N-methyl-d-aspartate receptor (NMDAR) dysfunction plays a crucial role in schizophrenia, leading to impairments in cognitive coordination. NMDAR agonists (e.g., glycine) ameliorate negative and cognitive symptoms, consistent with NMDAR models. However, not all types of cognitive coordination use NMDAR. Further, not all aspects of cognitive coordination are impaired in schizophrenia, suggesting the need for specificity in applying the cognitive coordination construct.
- Subjects
SCHIZOPHRENIA; NEURAL receptors; DISEASES; COGNITION disorders; SCHIZOTYPAL personality disorder; DISABILITY studies
- Publication
Behavioral & Brain Sciences, 2003, Vol 26, Issue 1, p93
- ISSN
0140-525X
- Publication type
Article
- DOI
10.1017/S0140525X0333002X