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- Title
Novel Antibacterial Agents 2022.
- Authors
Meneghetti, Fiorella; Barlocco, Daniela
- Abstract
This document is a special issue of the journal Pharmaceuticals, featuring 16 original articles, 3 reviews, and 1 communication. The articles focus on multidrug-resistant bacteria and explore different approaches using natural or synthetic compounds and innovative techniques. Topics covered include the potential therapeutic use of Sumra honey against MDR bacteria and fungi, the chemical profile and antimicrobial activity of Helichrysum italicum, the antimycobacterial activity of S. xanthocarpum extracts, and the development of new drugs for tuberculosis. The issue also discusses repurposing known drugs, hybridizing known scaffolds, and utilizing nanomaterials for antibacterial purposes. Additionally, three reviews examine the combination of β-lactam/β-lactamase inhibitors, bioactivity-based screening methods for antibiotic activity, and electrochemical sensing techniques for assessing antibiotic resistances. The text highlights two studies on the development of novel antimicrobial agents. The first study by Frida Svanberg Frisinger et al. focuses on a prototype drug called MAC13243, which targets a specific protein in Gram-negative bacteria. The drug demonstrated promising results in killing coliforms in fecal samples without disrupting the healthy gut microbiota. The second study by Marius Seethaler et al. presents a new synthesis method for fluorinated benzothiophene-indole hybrids, which proved effective against various strains of Staphylococcus aureus, including methicillin-resistant strains. Both studies contribute to the ongoing
- Subjects
ANTIBACTERIAL agents; ACETAMIDE; CARBAPENEM-resistant bacteria; METHICILLIN-resistant staphylococcus aureus; BIOACTIVE compounds; ACYL carrier protein; PEPTIDASE
- Publication
Pharmaceuticals (14248247), 2024, Vol 17, Issue 3, p370
- ISSN
1424-8247
- Publication type
Editorial
- DOI
10.3390/ph17030370