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- Title
Newly discovered knowledge pertaining to glucagon and its clinical applications.
- Authors
Kawamori, Dan; Sasaki, Shugo
- Abstract
Glucagon has been defined as an 'insulin counteracting hormone', which raises blood glucose levels. Recent progress in basic research has shown that glucagon is closely involved in glucose and amino acid metabolism. Additionally, its secretion is intricately, but precisely, regulated by various mechanisms involving molecules in addition to glucose, thus showing its critical role in systemic nutrient metabolism. An innovative dual‐antibody‐linked immunosorbent assay for glucagon that improves measurement accuracy has been developed, and substantial clinical findings have been obtained using this new system. This discovery expanded the pathophysiological significance of glucagon and accelerated the development of its clinical applications in diabetes.
- Subjects
GLUCAGON; AMINO acid metabolism; CLINICAL medicine; BLOOD sugar
- Publication
Journal of Diabetes Investigation, 2023, Vol 14, Issue 7, p829
- ISSN
2040-1116
- Publication type
Article
- DOI
10.1111/jdi.14009