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- Title
Microwave-Assisted Three-Component "Catalyst and Solvent-Free" Green Protocol: A Highly Efficient and Clean One-Pot Synthesis of Tetrahydrobenzo[b]pyrans.
- Authors
Santra, Sougata; Rahman, Matiur; Roy, Anupam; Majee, Adinath; Hajra, Alakananda
- Abstract
A green and highly efficient method has been developed for the one-pot synthesis of tetrahydrobenzo[b]pyrans via a threecomponent condensation of aldehydes, 1,3-cyclic diketones, and malononitrile under MW irradiation without using any catalyst and solvent. This transformation presumably occurs by a sequential Knoevenagel condensation, Michael addition, and intramolecular cyclization. Operational simplicity, solvent and catalyst-free conditions, the compatibility with various functional groups, nonchromatographic purification technique, and high yields are the notable advantages of this procedure.
- Subjects
SOLVENTS; BENZOPYRANS; CHEMICAL synthesis; MICROWAVE chemistry; KETONES; MICHAEL reaction
- Publication
Organic Chemistry International, 2014, p1
- ISSN
2090-200X
- Publication type
Article
- DOI
10.1155/2014/851924