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- Title
The Use of Marine Biota in Bone Tissue Regeneration: A Systematic Review.
- Authors
Machmud, Edy; Ikbal, Muhammad; Dammar, Irfan; Darmiaty
- Abstract
This systematic review tries to determine the use of the various types of marine biota in bone tissue regeneration. There were 637 articles gathered from PubMed, Wiley, and google scholar databases. Title selection obtained 172 reports and 69 duplications. Abstract selection resulted in 34 articles. The full-text selection was done afterward and produced 11 articles, which were finally analyzed by the authors. The research was done by 11 groups of researchers who came from 10 different countries. The countries were Spain, Tunisia, India, Brazil, Poland, Singapore, England, China, Malaysia, and South Africa. Marine biota that were used in the studies were shark teeth, pearl, fish skin, seaweed, sponge, cockle shell, and deep-sea fish head. The activated marker that appeared in the bone formation process by the stimulation of the material was alkaline phosphatase, collagen 1-a-1, osteopontin, osteocalcin, and runx2. Various types of marine biota dan are used in bone tissue regeneration through osteoblastic stimulation with the activity of bone formation markers, such as Alkaline phosphatase, collagen 1-a-1, osteocalcin, runx2, as well as other markers.
- Subjects
BONE regeneration; BIOTIC communities; OSTEOBLASTS; FISH skin; BONE growth; ALKALINE phosphatase
- Publication
Systematic Reviews in Pharmacy, 2020, Vol 11, Issue 12, p31
- ISSN
0975-8453
- Publication type
Article