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- Title
DMF Ameliorating Cerebral Ischemia/ Reperfusion Injury in Meal Rats.
- Authors
Abbas Al-Huesini, Laith M.; Al-Mudhaffer, Rhihab H.; Hassan, Saif M.; Hadi, Najahg R.
- Abstract
Cerebral I/R causes oxygen deprivation to the brain tissue and generation of reactive oxygen species (ROS) which can stimulate immune responses, leading to inflammatory cells activation and infiltration. Methods: Rats were subjected to general anesthesia during which an occlusion of bilateral common carotid arteries for half hour then reperfusion for one hour with and without pretreatment with Dimethyl fumarate (DMF) at 50 mg/kg intraperitoneal (i.p) 24 hr. before ischemia.HO-1, TLR2, and TLR4 antibodies were assessment by IHC technique while ELISA type used to measure Nrf2, NF-ĸB and MDA in brain tissue levels. Levels of nuclear Nrf2 were increased significantly ( P<0.05) in the DMF group. The levels of NF-ĸB and MDA were decreased significantly ( P<0.05). Histological findings including: hemorrhage, dark neurons, and necrosis were reduced in DMF groups in addition to the reduction in the infarction area. Neuroprotective effect of DMF against cerebral I/R injury probably occurred via up-regulation of nuclear Nrf2 and down-regulation of inflammatory and oxidative stress
- Subjects
REACTIVE oxygen species; REPERFUSION injury; CAROTID artery; RATS; OXIDATIVE stress
- Publication
Systematic Reviews in Pharmacy, 2019, Vol 10, Issue 1, p206
- ISSN
0975-8453
- Publication type
Article
- DOI
10.5530/srp.2019.1.36