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- Title
Immunophenotypic Demonstration of Two Natural Killer Surface Markers, H25 and H366, on Fresh Human Leukemic Cells.
- Authors
Körfer, Alfred; Kirchner, Hartmut; Schneekloth, Carsten; Bührer, Christoph; Wisniewski, David; Gulati, Subhash; Clarkson, Bayard; Knowles, Robert; Poliwoda, Hubert; Atzpodien, Jens
- Abstract
Using a modified alkaline-phosphatase/antialkaline-phosphatase method for phenotyping fresh human leukemias, we could demonstrate peripheral blood and bone marrow-derived blast cells to specifically react with two monoclonal antibodies (MoAbs), H25 and H366, previously shown to recognize natural killer cells, activated T lymphocytes and a proportion of normal hematopoietic precursor cells. MoAbs H25 and H366 were found to identify the majority of leukemic cells in patients presenting with T-ALL, LGL leukemia, pre-B-ALL, CML, and AML, respectively. Copyright © 1989 S. Karger AG, Basel
- Publication
Acta Haematologica, 1989, Vol 82, Issue 4, p193
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000205375