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- Title
Successful management of allergy to the insulin excipient metacresol in a child with type 1 diabetes: a case report.
- Authors
Wheeler, Benjamin J.; Taylor, Barry J.
- Abstract
<bold>Introduction: </bold>Insulin allergy to human insulin preparations during the treatment of diabetes is suggested to occur at rates ranging from <1.0% to 2.4%. These reactions vary from mild localized reactions, which resolve with repeated exposure, to life-threatening anaphylaxis and death. The management of persistent insulin allergy in type 1 diabetes mellitus is particularly complicated because ongoing treatment with insulin is essential.<bold>Case Presentation: </bold>We present the case of a 12-year-old Caucasian girl with localized allergy to the insulin excipient metacresol, and the subsequent desensitization therapy using continuous subcutaneous insulin infusion with simultaneous intravenous insulin infusion.<bold>Conclusions: </bold>This is the first documented case of allergy to the metacresol component of insulin in the pediatric type 1 diabetes literature. We describe an approach to diagnosis and management of metacresol allergy in type 1 diabetes.
- Subjects
DIABETES; PROINSULIN; PANCREATIC secretions; IMMUNOLOGIC diseases
- Publication
Journal of Medical Case Reports, 2012, Vol 6, Issue 1, p263
- ISSN
1752-1947
- Publication type
journal article
- DOI
10.1186/1752-1947-6-263