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- Title
Transient bilateral abducens neuropathy with post-tetanic facilitation and acute hypokalemia associated with oxaliplatin: a case report.
- Authors
Min-Han Tan; Wen Yee Chay; Jia Hui Ng; Bin Tean Teh; Lita Chew
- Abstract
Introduction: Oxaliplatin is a cytotoxic platinum compound that is in widespread use in the treatment of gastrointestinal cancers. It has been occasionally associated with acute motor neuropathy, but the precise mechanism is uncertain. To the best of our knowledge, we report the first case of a patient demonstrating posttetanic facilitation in the setting of transient bilateral abducens neuropathy and hypokalemia, after being infused with oxaliplatin. Case presentation: A 47-year-old Indian woman with metastatic gastric cancer was receiving an oxaliplatin infusion at the initiation of her third cycle of palliative chemotherapy. She developed acute bilateral abducens neuropathy with post-tetanic facilitation alongside acute laryngopharyngodysesthesia and hypokalemia. Following supportive management, including potassium infusion and warming, her neurological signs and symptoms were spontaneously resolved. This syndrome did not recur in subsequent cycles following prolongation of infusion duration and the addition of supportive calcium and magnesium infusions. Conclusion: The novel clinical observation of post-tetanic facilitation highlights a possible involvement of voltagegated channels at the presynaptic terminals in the mechanism of acute oxaliplatin neurotoxicity.
- Subjects
OXALIPLATIN; ANTINEOPLASTIC agents; CANCER patients; DRUG therapy
- Publication
Journal of Medical Case Reports, 2010, Vol 4, Issue 1, p1
- ISSN
1752-1947
- Publication type
Case Study
- DOI
10.1186/1752-1947-4-36