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- Title
Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports.
- Authors
Taramasso, Lucia; Dentone, Chiara; Alessandrini, Anna; Bruzzone, Bianca; Icardi, Giancarlo; Garraffo, Rodolphe; De Macina, Ilaria; Viscoli, Claudio; Di Biagio, Antonio; HIV/HCV Collaborative Liguria Group
- Abstract
In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i.e. enfuvirtide in the first case and etravirine in the second one.
- Subjects
DRUG resistance in microorganisms; HIV; HIV infections; VIRAL load; HIGHLY active antiretroviral therapy; TREATMENT effectiveness; CD4 lymphocyte count
- Publication
International Journal of STD & AIDS, 2015, Vol 26, Issue 11, p831
- ISSN
0956-4624
- Publication type
journal article
- DOI
10.1177/0956462414556330