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- Title
Synthesis of novel triarylmethane derivatives containing a trichloropyrimidine moiety.
- Authors
Rezazadeh-Jabalbarezi, Fatemeh; Ranjbar-Karimi, Reza; Mohammadiannejad, Kazem; Atabaki, Fariborz
- Abstract
Firstly, the nucleophilic substitution reactions of 2,4,5,6-tetrachloropyrimidine (TCP) with hydroxybenzaldes 2a–c were employed to synthesize ((2,5,6-trichloropyrimidin-4-yl)oxy)benzaldehydes 3a–c. The fully characterization of the derived products clearly confirms that the nucleophilic attack of nucleophiles takes place at C-4 position of TCP, regioselectivity. Likewise, a clear preference for the nucleophilicity of 2a over 2b and 2c was observed in these reactions. Secondly, the solvent-less Friedel–Crafts alkylation reactions of arenes/heteroarenes with the derived aldehydes catalyzed by SiO2-H2SO4 were applied to synthesize a novel series of triarylmethane derivatives containing a trichloropyrimidine moiety. The chemical structures of all the compounds were elucidated by FT-IR, NMR spectra and elemental analyses.
- Subjects
NUCLEOPHILIC substitution reactions; FRIEDEL-Crafts reaction; MOIETIES (Chemistry); NUCLEOPHILIC reactions; ELEMENTAL analysis
- Publication
Journal of the Iranian Chemical Society, 2023, Vol 20, Issue 12, p2917
- ISSN
1735-207X
- Publication type
Article
- DOI
10.1007/s13738-023-02888-6