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- Title
Carcinoma intraepitelial tubárico seroso como hallazgo posquirúrgico de endometriosis y útero miomatoso. Reporte de un caso.
- Authors
Luque-González, Pablo; Requerey-Fernández, Mercedes; Frías-Sánchez, Zoraida; Guadix-Martín, María del Pilar; Jiménez-Caraballo, Antonio; Gutiérrez-Domingo, Álvaro; Pantoja-Garrido, Manuel
- Abstract
BACKGROUND: Serous tubal intraepithelial carcinoma (STIC) is a precursor lesion of invasive high-grade tubal and serous carcinoma of the ovary, frequently diagnosed in the context of prophylactic bilateral salpingoophorectomy for benign gynecological pathology. The objective of this work is to carry out a literature review on the most relevant aspects of the follow-up of this injury, after its incidental diagnosis in gynecological surgery. CLINICAL CASE: A 51-year-old nulliparous patient who, in the context of a clinical situation of abdominal pain with elevation of tumor markers CA125 and CA19.9, was diagnosed with polymomatous uterus and suspected endometrioma in the right ovary. After a subtotal hysterectomy with bilateral adnexectomy, the histological study of the excised tubal specimen found microscopic foci of STIC without signs of stromal invasion. Given this finding, breast imaging tests and a genetic study of the BRCA 1/2 mutation was requested. CONCLUSION: Prophylactic bilateral salpingoophorectomy in gynecological surgery is a procedure that can reduce the risk of developing peritoneal, tubal, and serous ovarian carcinomas. Patients diagnosed with STIC should be subsidiaries of follow-up based on ultrasound controls, mammary imaging tests, tumor markers, and genetic studies, due to their association in many cases with mutations in the BRCA 1/2 genes. It is necessary to establish a series of standardized clinical protocols for the management of patients with STIC and to continue advancing our understanding of this pathology and its subsequent evolution to high-grade serous carcinoma.
- Subjects
ENDOMETRIOSIS; MYOMETRIUM tumors; TUMOR markers; UTERINE fibroids; ABDOMINAL pain; HYSTERECTOMY; DIAGNOSTIC ultrasonic imaging; MEDICAL protocols
- Publication
Ginecología y Obstetricia de México, 2020, Vol 88, Issue 9, p625
- ISSN
0300-9041
- Publication type
Article