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- Title
Estrategia combinada en fertilización in vitro: mínima estimulación y transferencia de embrión único con diagnóstico genético. Experiencia de 3 años en dos centros de reproducción en México.
- Authors
Magaly Sánchez-González, Cristina; Aguinaga-Ríos, Mónica; García-Sánchez, Rodolfo; Sánchez-González, Dante; Guarneros-Valdovinos, Rodrigo; Chávez-Badiola, Alejandro
- Abstract
OBJECTIVE: To evaluate results of a combined approach in IVF, using minimal stimulation, preimplantation genetic testing for aneuploidy, and single blastocyst transfer. MATERIALS AND METHODS: Retrospective cohort study over a three years' period in two fertility centers in Mexico. A total of 125 patients were included, between 25 and 45 years old, with minimal stimulation IVF, preimplantation genetic testing for aneuploidy (PGT-A) and single euploid embryo transfer. PGT was performed using microarrays and next generation sequencing (NGS). RESULTS: A total of 175 cycles (mean age: 39 years old) were analyzed in 125 patients. On average, five eggs were collected per cycle; fertilization rate was 86.57%; blastocyst rate was 50.7% per fertilized egg. Only 33% of embryos were euploid. Pregnancy rate per transferred embryo was 71%. Live birth rate was 60.8% (42 births). CONCLUSIONS: A combination of minimal stimulation, PGT-A and single blastocyst embryo transfer can yield a high live birth rate.
- Subjects
MEXICO; FERTILIZATION in vitro; GENETIC testing; HUMAN embryos; EMBRYO implantation; BIRTH rate; BLASTOCYST; ANEUPLOIDY
- Publication
Ginecología y Obstetricia de México, 2020, Vol 88, Issue 8, p508
- ISSN
0300-9041
- Publication type
Article
- DOI
10.24245/gom.v88i8.3490