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- Title
Establishment of Reference Values for Pepsinogens in Healthy Subjects of the Gansu Province: a Cross-Sectional Study.
- Authors
Li Yan; Xiumei Yuan; Yu Tang; Xingwen Yang; Xiaoyan Yang; Fenghui Zhao; Yan Lu; Lianhua Wei; Xiaoyan Fu; Wanxia Wang; Yanjuan Jia; Yuchun Si; Dehong Li
- Abstract
Background: At present, the pepsinogen reference values applicable to subjects from Gansu province have not been established. Therefore, the current study aimed to establish reference values for PGI, PGII, and the PGI/PGII ratio in Gansu Province, Northwest China. Methods: The present study was a cross-sectional study. Following screening in the physical examination center of Gansu Provincial Hospital, 2,130 healthy subjects were enrolled (age range 18 - 88 years; BMI range 15.35 - 38.89 kg/m2) from March 2018 to December 2020. Serum PGI and PG II concentration levels were detected by chemiluminescence. The reference values were defined according to age and gender by non-parametric 95th percentile intervals. Results: The increase in age caused a gradual increase in the levels of PG I and PG II, while PG I/PG II ratio gradually decreased. The PG I, PG II and PG I/PG II ratio in males were significantly higher than those in females. The reference values for PG I, PG II and PG I/PG II ratio in males: < 40 years old were 22.79 - 119.79 ng/mL, 3.02 - 21.57 ng/mL, and 2.99 - 10.25, respectively; = 40 years old were 17.58 - 125.12 ng/mL, 3.70 - 25.84 ng/mL, and 1.52 - 10.53, respectively. The reference values for PG I, PG II, and PG I/PG II ratio in females: < 40 years old were 22.57 - 103.90 ng/mL, 3.17 - 20.73 ng/mL, and 2.28 - 10.46, respectively; = 40 years old were 14.24 - 117.81 ng/mL, 3.36 - 29.57 ng/mL, and 1.26 - 9.85, respectively. Conclusions: The present study determined the missing reference values of serum PGs for healthy subjects of different gender and ages in Gansu Province.
- Subjects
GANSU Sheng (China); REFERENCE values; CROSS-sectional method; PEPSINOGEN; PROVINCES; CHEMILUMINESCENCE; INDUCED labor (Obstetrics)
- Publication
Clinical Laboratory, 2022, Vol 68, Issue 7, p1469
- ISSN
1433-6510
- Publication type
Article
- DOI
10.7754/Clin.Lab.2021.211020