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- Title
Catalytic Hydroxyethylation of Phenols with Renewable Ethylene Glycol Diester as an Alternative to Ethylene Oxide.
- Authors
Luo, Yu‐Ji; Li, Zhi
- Abstract
Polyol esters are abundant bio‐based resources. Integration of polyol esters into the production chain of fine chemicals would reduce carbon emissions and improve the sustainability of the chemical industry. An efficient synthetic route to phenoxyethanols was developed through catalytic hydroxyethylation of phenols with ethylene glycol diacetate as the reagent. This method showed the potential of ethylene glycol diester as a safe and sustainable substitute for ethylene oxide, a useful but toxic reagent. A variety of phenoxyethanol esters were produced in high yield under simple catalytic conditions. Mechanistic studies revealed that the reaction underwent a neighboring group participation process.
- Subjects
ETHYLENE glycol; ETHYLENE oxide; POLYOLS; PHENOLS; PHENOL; CHEMICAL industry
- Publication
European Journal of Organic Chemistry, 2024, Vol 27, Issue 24, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202400158