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- Title
Water‐Promoted Michael Addition Reaction of Sulfonyl Hydrazides and α, β‐Unsaturated Propionic Acids to 3‐Sulfone Propionic Acids.
- Authors
Qi, Zhiyuan; Liu, Yifan; Zhang, Qilong; Zhao, Panfeng; Gao, Lingfeng; Sun, Xu; Zheng, Gengxiu
- Abstract
A water‐promoted synthesis methodology for constructing 3‐sulfone propionic acids from sulfonyl hydrazides and α, β‐unsaturated propionic acids with excellent yields were reported. The green synthesis methodology was promoted by water without any catalyst, ligand and organic solvent. The D2O control experiment sufficiently proved that the 2‐hydrogen atom of 3‐sulfone propionic acid come from water. Moreover, the 3‐sulfone propionic acid derivates could be directly purified by crystallization without column chromatography.
- Subjects
MICHAEL reaction; PROPIONIC acid; SULFONYL compounds; HYDRAZIDES; SULFONES; CATALYSTS; COLUMN chromatography; ORGANIC solvents
- Publication
European Journal of Organic Chemistry, 2022, Vol 2022, Issue 16, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202101456