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- Title
Macrophage colony stimulating factor involvement in uremic patients.
- Authors
Le Meur, Yannick; Fixe, Philippe; Aldigier, Jean-Claude; Leroux-Robert, Claude; Praloran, Vincent
- Abstract
The immunodeficiency of patients with chronic renal failure (CRF) is related 10 multiple and complex alterations of the cytokine network and of its target cells such as T or B lymphocytes, monocytes, fibroblasts or endothelial cells. Chronic activation of monocytic functions is recognized as a key factor in these immunological disorders. Since macrophage colony stimulating factor (M-CSF) is essential for the activation of several functions of monocytes and macrophages and their production of cytokines such as interteukin-1, interleukin-6, and tumor necrosis factor α, we investigated its involvement in patients with CRF. When measured by ELISA, M-CSF serum levels were significantly higher in patients with progressive CRF and those on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) than in controls. M-CSF serum levels did not correlate with the degree of renal insufficiency and were probably related to complex alterations in its production and/or degradation by the specific M-CSF receptors of macrophages. In HD patients the M-CSF serum concentrations inversely correlated with the number of circulating lymphocytes and were significantly higher in anemic patients requiring treatment with erythropoietin. Our results suggest that M-CSF may play a role in altering the immune system in uremic patients by maintaining in the circulation and tissues permanently primed monocytes and/or macrophages that can then be triggered to an activated state by secondary stimuli such as endotoxins, complement components, other cytokines or contact with foreign surfaces.
- Subjects
IMMUNOLOGY; CHRONIC kidney failure; CYTOKINES; UREMIA; MACROPHAGES; NEPHROLOGY
- Publication
Kidney International, 1996, Vol 50, Issue 3, p1007
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1996.402