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- Title
The role of arterial hypertension in progression of renal failure.
- Authors
Kes, Petar; Ratković-Gusić, Iva
- Abstract
The effect of arterial hypertension on the progression of chronic renal failure (CRF) was evaluated in 108 patients who eventually required dialysis in the 8 year period of the study. Patients' average serum creatinine (SCr) concentration at first examination was 239.7 ± 45.3 µmol/liter and at the start of dialysis was 1,661.0 ± 181.9 µmol/liter. The mean duration of pre-dialysis follow-up was 53.7 ± 15.7 months. The mean monthly increase in SCr was 18.8 ± 13.4 and 2.1 ± 1.4 µmol/liter/month in hypertensive and normotensive CRF patients, respectively (P < 0.001). The CRF patients with a diastolic blood pressure (BP) < 89 mm Hg had a significantly (P < 0.05) slower rate of decline in renal function than the patients with a diastolic BP ≥ 90 mm Hg. There was a significant relationship between a mean diastolic BP ≥ 90 mm Hg and the rate of monthly increase in SCr (r = 0.81, P < 0.001). These data indicate that control of diastolic BP in CRF patients is a potentially effective way to slow the rate of decline in renal function.
- Subjects
BLOOD circulation disorders; HYPERTENSION; KIDNEY diseases; BLOOD plasma; CHRONIC kidney failure; DIALYSIS (Chemistry); DIFFUSION; CREATININE; BLOOD pressure
- Publication
Kidney International, 1996, Vol 49, pS72
- ISSN
0085-2538
- Publication type
Article