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- Title
Prognostic relevance of aberrant SOCS-1 gene promoter methylation in myelodysplastic syndromes patients.
- Authors
Chaubey, R.; Sazawal, S.; Mahapatra, M.; Chhikara, S.; Saxena, R.
- Abstract
Introduction: The inactivation of suppressor of cytokine signaling SOCS-1, a negative regulator of cytokine pathways, by hypermethylation was shown in hematological malignancies including Myelsplastic Syndromes. So far, its prognostic relevance in myelodysplastic syndromes (MDS) patients has not been understood. Methods: Methylation status of SOCS-1 gene was analyzed in series of 100 patients using methylation-specific PCR (MS-PCR) and correlated with disease severity, progression, and survival by comparing prognostic factors such as hematological, clinical, and cytogenetics. Results: Of the total of 100 MDS patients analyzed, methylation of SOCS1 gene was found in 53% patients. Also, the frequency of patients with poor and intermediate cytogenetics was observed significantly high in methylated group (P < 0.001). Moreover, the patients with methylated SOCS-1 gene had significantly more frequent disease progression as compared to the patients with unmethylated SOCS-1 gene (P < 0.006). Both progression-free survival and median overall survival were significantly shorter in patients with methylated SOCS-1 gene when compared to the patients with unmethylated SOCS-1 gene (P = 0.006 & P = 0.001, respectively). Conclusion: This study for the first time showed that the mathylation of SOCS-1 gene plays an important role in the disease progression and is associated with poor survival especially among the high-risk patients. This may be due to high association between SOCS1 methylation and higher risk subtypes of MDS (such as RAEB) in this study.
- Subjects
INDIA; CHI-squared test; CHROMOSOME banding; FISHER exact test; LONGITUDINAL method; MYELODYSPLASTIC syndromes; PROBABILITY theory; PROGNOSIS; STATISTICS; SURVIVAL; DATA analysis; SEVERITY of illness index; DISEASE progression; DATA analysis software; DNA methylation; SIGNAL peptides; DESCRIPTIVE statistics; KAPLAN-Meier estimator; GENETICS
- Publication
International Journal of Laboratory Hematology, 2015, Vol 37, Issue 2, p265
- ISSN
1751-5521
- Publication type
Article
- DOI
10.1111/ijlh.12283