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- Title
Binaural Gain Modulation of Spectrotemporal Tuning in the Interaural Level Difference-Coding Pathway.
- Authors
Steinberg, Louisa J.; Fischer, Brian J.; Pena, Jose L.
- Abstract
In the brainstem, the auditory system diverges into two pathways that process different sound localization cues, interaural time differ-ences (ITDs) and level differences (ILDs). We investigated the site where ILD is detected in the auditory system of barn owls, the posterior part of the lateral lemniscus (LLDp). This structure is equivalent to the lateral superior olive in mammals. The LLDp is unique in that it is the first place of binaural convergence in the brainstem where monaural excitatory and inhibitory inputs converge. Using binaurally uncorrelated noise and a generalized linear model, we were able to estimate the spectrotemporal tuning of excitatory and inhibitory inputs to these cells. We show that the response of LLDp neurons is highly locked to the stimulus envelope. Our data demonstrate that spectrotemporally tuned, temporally delayed inhibition enhances the reliability of envelope locking by modulating the gain of LLDp neurons' responses. The dependence of gain modulation on ILD shown here constitutes a means for space-dependent coding of stimulus identity by the initial stages of the auditory pathway.
- Subjects
BINAURAL hearing aids; TEMPORAL bone radiography; INTERAURAL time difference; AUDITORY pathways; BRAIN stem; BARN owl
- Publication
Journal of Neuroscience, 2013, Vol 33, Issue 27, p11089
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.4941-12.2013