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- Title
Use of an antispasmodic (rociverine) to shorten the length of labor: a randomized, placebo-controlled trial.
- Authors
CROMI, ANTONELLA; GHEZZI, FABIO; AGOSTI, MASSIMO; UCCELLA, STEFANO; PIAZZA, NICOLETTA; SERATI, MAURIZIO; BOLIS, PIERFRANCESCO
- Abstract
Objective. To determine the effectiveness of rociverine, an antispasmodic drug, for reducing the duration of labor among nulliparous women managed according to a standard intrapartum protocol. Design. Randomized controlled trial. Setting. An academic tertiary care hospital. Population. Nulliparae in spontaneous active labor, with cervical dilatation between 3 and 5cm. Methods. Participants were randomly assigned to receive either an intramuscular injection of 20mg rociverine ( n=55) or the same volume of saline ( n=56). Main Outcome Measure. Cervical dilatation rate (from administration of study drug to full dilatation). Results. Laboring women who received rociverine had faster cervical dilatation than those assigned to placebo (2.43±1.84 vs. 1.85±1.38cm/hour, p=0.03). The time interval from treatment administration to full cervical dilatation was shorter in the rociverine group than in the placebo group (220±125 vs. 278±129min, p=0.04). No difference was found in any other obstetric outcome. No adverse effects have been recorded from rociverine administration. Conclusions. Intrapartum administration of rociverine to nulliparous women may help to reduce the duration of the first stage of labor in a context of uniform labor management.
- Subjects
ANTISPASMODICS; LABOR (Obstetrics); RANDOMIZED controlled trials; PLACEBOS; CHILDBIRTH
- Publication
Acta Obstetricia et Gynecologica Scandinavica, 2011, Vol 90, Issue 12, p1371
- ISSN
0001-6349
- Publication type
Article
- DOI
10.1111/j.1600-0412.2011.01265.x