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- Title
Asthma and obesity as predictors of severe obstructive sleep apnea in an adolescent pediatric population.
- Authors
Narayanan, Ajay; Yogesh, Ahana; Mitchell, Ron B.; Johnson, Romaine F.
- Abstract
<bold>Objective: </bold>To study a cohort of children referred for full-night polysomnography (PSG) due to suspicion of obstructive sleep apnea (OSA). We examined the relationship between asthma, obesity, and severe OSA (sOSA).<bold>Methods: </bold>We performed a retrospective case control analysis of children, ages 9 to 17 years, who underwent full-night PSG. The primary goal was to determine the association between asthma, obesity, and sOSA (apnea-hypopnea index ≥10). We used multiple logistic regression analysis to estimate these associations after controlling for covariates. A P value of ≤.05 was considered significant.<bold>Results: </bold>The study included 367 children (mean [standard deviation] age 14 years (1.7), 56% male, 43% Hispanic). The prevalence of asthma was 188 of 367 (52%); obesity was 197 of 367 (54%); and sOSA was 109 of 367 (30%). sOSA was less likely in asthmatics (coefficient = -0.59; standard error [SE] = 0.23; P = .01; odds ratio [OR] = 0.55; 95% confidence interval [CI] = 0.34 to 0.88) and more likely with obesity (coefficient = 0.89; SE = 0.24; P < .001; OR = 2.4; 95% CI = 1.5 to 3.9). The presence of asthma reduced the likelihood of sOSA by an average of 14% among obese patients and 9% among nonobese patients. These associations held even after controlling for age, sex, race, income, and tonsillar hypertrophy.<bold>Conclusion: </bold>The presence of asthma reduced, whereas obesity increased the likelihood of sOSA among a large cohort of older children referred for PSG. These relationships were additive. Further research is indicated regarding these relationships.<bold>Level Of Evidence: </bold>3b Laryngoscope, 130:812-817, 2020.
- Subjects
SLEEP apnea syndromes; ASTHMA; OBESITY; SLEEP apnea syndromes in children; SLEEP disorders in adolescence; CHILDHOOD obesity; CASE-control method; RETROSPECTIVE studies; SEVERITY of illness index; DISEASE complications
- Publication
Laryngoscope, 2020, Vol 130, Issue 3, p812
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1002/lary.28029