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- Title
Predictive Accuracy of First Post-Treatment PET/CT in HPV-Related Oropharyngeal Squamous Cell Carcinoma.
- Authors
Koshkareva, Yekaterina; Branstetter, Barton F.; Gaughan, John P.; Ferris, Robert L.
- Abstract
Objectives/Hypothesis: To determine whether the result of first posttreatment positron emission tomography and computed tomography (PET/CT) is predictive of outcome in patients with oropharyngeal squamous cell carcinoma (OPSCC), and whether PET/CT accuracy is affected by human papillomavirus (HPV) status. Study Design: Retrospective review. Methods: Demographic, clinical, and radiographic data were available for 61 patients with OPSCC, treated in 2004 to 2012 at a single tertiary academic referral center, with at least one baseline and one posttreatment PET/CT. Clinical followup was obtained every 3 months thereafter. The median follow-up time was 36 months (range 3-100 months). Results: Of 61 patients, 48 (79%) had negative first posttreatment PET/CT results; and overall, 18 of the 61 patients (30%) recurred. All accuracy measures for PET/CT were higher in HPV-positive patients, including a 93% negative predictive value (NPV). Patients with positive PET/CT results had poorer survival on Kaplan-Meier analyses. On multivariate analysis of factors predictive of recurrence, two parameters were significant: HPV status (P50.0046) and PET/CT result (P <0.0001). Conclusions: A negative first posttreatment PET/CT result is associated with better prognosis and rare recurrence, especially in patients with HPV-positive status. Less frequent radiologic surveillance is warranted in patients with HPVpositive OPSCC and a negative first posttreatment PET/CT scan.
- Subjects
OROPHARYNGEAL cancer; POSITRON emission tomography; COMPUTED tomography; PAPILLOMAVIRUS diseases; CANCER relapse; PROGNOSIS
- Publication
Laryngoscope, 2014, Vol 124, Issue 8, p1843
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.24617