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- Title
Retinoic acid‐loading of the major birch pollen allergen Bet v 1 may improve specific allergen immunotherapy: In silico, in vitro and in vivo data in BALB/c mice.
- Authors
Hufnagl, Karin; Afify, Sheriene Moussa; Braun, Nina; Wagner, Stefanie; Wallner, Michael; Hauser, Michael; Wiederstein, Markus; Gadermaier, Gabriele; Wildner, Sabrina; Redegeld, Frank A.; Blokhuis, Bart R.; Hofstetter, Gerlinde; Pali‐Schöll, Isabella; Roth‐Walter, Franziska; Pacios, Luis F.; Jensen‐Jarolim, Erika
- Abstract
Retinoic acid-loading of the major birch pollen allergen Bet v 1 may improve specific allergen immunotherapy: In silico, in vitro and in vivo data in BALB/c mice Even if this was not due to altered endolysosomal stability of Bet v 1a due to RA binding (Figure S3), it seemed so far like RA-loading transforms the hyperallergen Bet v 1a to a hypoallergen with improved tolerogenic capacity of potential implications for allergen immunotherapy. Mice were first made allergic against the major birch pollen allergen Bet v 1a and subsequently treated intranasally with either the I apo i -Bet v 1a, or with the RA-loaded I holo i -Bet v 1a, or as a control with RA alone.
- Subjects
IMMUNOGLOBULIN E; TRETINOIN; POLLEN; ALLERGENS; BIRCH; IMMUNOTHERAPY
- Publication
Allergy, 2020, Vol 75, Issue 8, p1
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.14259