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- Title
The importance of being not significant: Blood eosinophils and clinical responses do not correlate in severe asthma patients treated with mepolizumab in real life.
- Authors
Bagnasco, Diego; Massolo, Alessandro; Bonavia, Marco; Brussino, Luisa; Bucca, Caterina; Caminati, Marco; Canonica, Giorgio Walter; Caruso, Cristiano; D'Amato, Maria; De Ferrari, Laura; Guida, Giuseppe; Heffler, Enrico; Lombardi, Carlo; Menzella, Francesco; Milanese, Manlio; Paoletti, Giovanni; Riccio, Anna Maria; Rolla, Giovanni; Senna, Gianenrico; Testino, Elisa
- Abstract
Abbreviations ACT asthma control test EOS eosinophils FeNO fractional exhaled nitric oxide FEV1 forced expiratory volume in 1 second MAbs monoclonal antibodies OCS oral corticosteroids The availability of monoclonal antibodies (MAbs) has changed the therapeutic approach to severe asthma, defined by the ERS/ATS document as asthma that remains not controlled despite the maximum inhaled treatment, and that often requires the use of systemic corticosteroids (OCS). GLO:1X5/01jun20:all14135-fig-0001.jpg PHOTO (COLOR): The figure shows patient by patient the % change of parameters vs baseline (Y-axis) and the baseline eosinophil count (X-axis).
- Subjects
ASTHMATICS; EOSINOPHILS; FALSE positive error
- Publication
Allergy, 2020, Vol 75, Issue 6, p1460
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.14135